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患儿男,10岁8个月,因非霍奇金淋巴瘤入院化疗。于化疗第8、15、22天静脉推注长春新碱2mg,1次/d,并同时静脉泵入柔红霉素50mg。第3次使用柔红霉素后42h,患儿突然神志不清,瞳孔散大,对光反射消失,呼吸停止,血压测不出,心室颤动。心电图示心脏停搏。急行抢救措施,2min后出现窦性心律,意识逐渐恢复。之后又出现2次类似发作,每次持续约10min。3d后24h心电图示单发房性早搏9次、室性早搏1次,全程ST段改变。随诊2年,患者未再用柔红霉素,长春新碱继续使用,未再出现类似发作。
Children male, 10 years and 8 months, due to non-Hodgkin’s lymphoma admission chemotherapy. On the 8th, 15th, and 22nd days of chemotherapy, vincristine 2mg was injected intravenously once a day, and at the same time, daunorubicin 50mg was intravenously pumped. 42h after the third use of daunorubicin, children suddenly unconscious, mydriasis, light reflex disappeared, respiratory arrest, blood pressure can not be measured, ventricular fibrillation. ECG shows cardiac arrest. Emergency measures, sinus rhythm after 2min, consciousness gradually restored. Then there are 2 similar episodes, each lasting about 10min. 24h after 3d ECG showed single atrial premature beats 9 times, premature ventricular contractions 1, the entire ST segment changes. Follow-up 2 years, the patient did not re-daunorubicin, vincristine continue to use, no recurrence of similar attacks.