c-ski是v-ski细胞内的同源物,在不同类型的组织和细胞中分布广泛。过量表达的ski可促进鸡胚成纤维细胞增殖,诱导其肌肉分化,但却抑制小鼠胚胎成纤维细胞增殖。c-ski还可调节多种核因子的转录活性,参与神经系统发育、造血细胞的增殖和分化、肿瘤发生、组织再生等多种生理病理过程。现综述c-ski的主要研究进展。 c-ski is a homolog in v-ski cells that is widely distributed in different types of tissues and cells. Overexpression of ski promoted embryonic fibroblasts proliferation and induced their muscle differentiation, but inhibited the proliferation of mouse embryonic fibroblasts. c-ski can also regulate a variety of nuclear factor transcriptional activity, involved in nervous system development, hematopoietic cell proliferation and differentiation, tumorigenesis, tissue regeneration and other physiological and pathological processes. Now summarize the main research progress of c-ski.