Dear Editor,hCLP46 (human CAP10-like protein 46 kDa) was initially isolated and identified from human acute myeloid leukemia transformed from myelodysplastic syndrome (MDS-AML) CD34+ cells (Teng et al., 2006) and we demonstrated previously that hCLP46 is abnormally expressed in many hematopoietic malignancies (Wang et al., 2010).Studies from its Drosophila homolog, Rumi, suggested that Notch is apotential target of hCLP46 (Acar et al., 2008).