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目的探讨~(18)氟-氟代脱氧葡萄糖(~(18)F-FDG)PET/CT在乳腺癌术后复发、转移患者的应用价值。方法回顾性分析乳腺癌术后临床怀疑复发或转移的49例患者的~(18)F-FDG PET/CT影像资料,并与同期传统影像学检查资料、血清肿瘤标记物和病理及临床随访结果进行对比。结果~(18)F-FDG PET/CT诊断乳腺癌术后复发及转移的灵敏度、特异度、准确性、阳性预测值和阴性预测值分别为81.6%、90.9%、83.7%、96.9%和58.8%。在血清肿瘤标记物升高的30例患者中,18 F-FDG PET/CT诊断乳腺癌术后复发及转移的灵敏度、特异度、准确性、阳性预测值和阴性预测值分别为84.6%、100%、86.7%、100%和50.0%。依据~(18)F-FDG PET/CT结果,73.5%患者更改了治疗方案。结论 ~(18)F-FDG PET/CT能有效评估乳腺癌术后复发及转移病例,指导临床治疗。
Objective To investigate the value of 18F-18F-FDG PET / CT in the patients with recurrent and metastatic breast cancer. Methods The data of ~ (18) F-FDG PET / CT in 49 patients with clinically suspected breast cancer recurrence or metastasis were analyzed retrospectively. The results were compared with those of conventional imaging examination, serum tumor markers and pathology and clinical follow-up comparing. Results The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of ~ (18) F-FDG PET / CT in diagnosis of postoperative recurrence and metastasis of breast cancer were 81.6%, 90.9%, 83.7%, 96.9% and 58.8 %. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of 18 F-FDG PET / CT in diagnosing breast cancer recurrence and metastasis were 84.6% and 100% respectively in 30 patients with elevated serum tumor markers %, 86.7%, 100% and 50.0%. Based on ~ (18) F-FDG PET / CT findings, 73.5% of patients changed their regimen. Conclusion ~ (18) F-FDG PET / CT can effectively evaluate the postoperative recurrence and metastasis of breast cancer and guide the clinical treatment.