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[目的]研究胃癌CD44v6的表达及意义。[方法]应用免疫组织化学ABC法 ,研究85例胃癌手术标本中CD44v6的表达。[结果]胃癌原发灶中CD44v6表达阳性率为61 2%(52/85)。CD44v6表达阳性率在进展期胃癌(66 7%)、累及浆膜层胃癌(72 2%)、淋巴结阳性胃癌(73 2%)均高于早期胃癌(30 8%)、未累及浆膜层胃癌(41 9%)、淋巴结阴性胃癌(37 9%)(P<0 05或P<0 01)。[结论]CD44v6可能参与胃癌的浸润和淋巴结转移过程。检测胃癌CD44v6的表达 ,有助于对胃癌生物学行为的了解及对患者预后的判断
[Objective] To study the expression and significance of CD44v6 in gastric cancer. [Methods] Immunohistochemical ABC method was used to study the expression of CD44v6 in 85 specimens of gastric cancer. [Results] The positive rate of CD44v6 expression in primary gastric cancer was 61 2% (52/85). The positive rate of CD44v6 expression in advanced gastric cancer (66 7%), invasive serosa (72 2%), and lymph node positive (73 2%) was higher than that in early gastric cancer (30 8%), but not in serosa. (41%), lymph node-negative gastric cancer (37%) (P <0 05 or P <0 01). [Conclusion] CD44v6 may be involved in the invasion and lymph node metastasis of gastric cancer. Detecting the expression of CD44v6 in gastric cancer is helpful for understanding the biological behavior of gastric cancer and judging the prognosis of patients