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对136例2型糖尿病患者根据有无视网膜病变及病变程度分为三组,无视网膜病变组(NDR),非增值性视网膜病变(NPDR)和增值性视网膜病变(PDR),测定其空腹及餐后2小时血清C肽水平,及其他可能影响视网膜病变发展的因素并进行统计分析。结果与NDR组比较:空腹C肽(FCP)在NPDR组和PDR组降低,差异有统计学意义(均P<0.01),PDR组更低于NPDR组(P<0.05);餐后2小时C肽(PCP)在NPDR组和PDR明显低于NDR组,差异有统计学意义(均P<0.01),PDR组低于NPDR(P<0.01);糖尿病病程、尿白蛋白肌酐比值(ACR)在PDR组明显高于NDR(均P<0.01)和NPDR组(均P<0.05),在NPDR组高于NDR组(均P<0.05);logistic回归分析显示,PCP、糖尿病病程、GHbA1c、ACR、SBP与2型糖尿病视网膜病变独立相关。结论餐后2小时C肽水平降低是2型糖尿病视网膜病变发展的危险因素。
136 patients with type 2 diabetes were divided into three groups according to the presence or absence of retinopathy and the degree of lesion, without retinopathy (NDR), non-proliferative retinopathy (NPDR) and proliferative retinopathy (PDR) Two hours after serum C-peptide levels, and other factors that may affect the development of retinopathy and statistical analysis. Results Compared with NDR group, fasting C-peptide (FCP) decreased in NPDR group and PDR group (all P <0.01), in PDR group was lower than that in NPDR group (P <0.05) (P <0.01), PDR group was lower than NPDR (P <0.01); Diabetes course and urinary albumin creatinine ratio (ACR) were significantly lower in NPDR group and PDR group than in NDR group PDR group was significantly higher than NDR group (all P <0.01) and NPDR group (all P <0.05), and higher in NPDR group than in NDR group (all P <0.05). Logistic regression analysis showed that PCP, duration of diabetes, GHbA1c, SBP is independently associated with type 2 diabetic retinopathy. Conclusion The decrease of C-peptide level at 2 hours postprandial is a risk factor for the development of type 2 diabetic retinopathy.