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目的探讨恶性肿瘤患者院内细菌感染的危险因素。方法收集2009年1月至2011年12月大连医科大学附属二院肿瘤内科恶性肿瘤院内细菌感染的98例患者的临床资料,对感染相关高危因素采用单因素及Logistic多因素回归分析。结果单因素分析显示性别、感染部位、留置导尿、WBC下降程度及PS评分与G+/G-菌感染种类有关(P<0.05),但进一步进行多因素分析后显示只有性别和留置导尿对细菌感染种类有影响(OR值分别为0.257、7.726);细菌种类、性别、深静脉置管及化疗疗程数是血液感染发生的危险因素(OR值分别为8.634、8.000、2.012、0.025)。结论女性较男性更易发生G+菌感染,而留置导尿则以发生G-菌感染为主;G-菌感染、女性、深静脉置管及多疗程化疗者易发生血液感染。应针对各种危险因素采取有效的预防措施,减少恶性肿瘤患者院内细菌感染的发生。
Objective To investigate the risk factors of nosocomial bacterial infection in patients with malignant tumors. Methods The clinical data of 98 patients with bacterial infection in the Department of Medical Oncology of the Second Affiliated Hospital of Dalian Medical University from January 2009 to December 2011 were collected. Univariate and Logistic regression analysis were used to analyze the risk factors related to infection. Results Univariate analysis showed that gender, location of infection, indwelling catheterization, degree of decline of WBC and PS score were related to the type of G + / G-infection (P <0.05). However, after further multivariate analysis, only gender and indwelling catheterization (OR = 0.257 and 7.726, respectively). Bacterial species, sex, catheterization and chemotherapy were the risk factors for blood infection (ORs: 8.634, 8.000, 2.012, 0.025, respectively). Conclusions Female is more likely to have G + infection than male, while indwelling catheterization is predominantly G-infection. G-infection, female, deep-vein catheterization and multi-course chemotherapy are prone to have blood infections. Effective prevention measures should be taken for various risk factors to reduce the occurrence of nosocomial bacterial infections in patients with malignant tumors.