目的制备杜香油纳米乳并进行质量评价。方法以Tween80、Cremophor EL、泊洛沙姆188为乳化剂,乙醇、1,2-丙二醇、PEG400为助乳化剂,杜香油为油相,通过伪三元相图筛选出杜香油纳米乳的最佳处方,并对其形态特征、稳定性进行考察。结果最优处方为:Tween80∶无水乙醇∶杜香油∶水=3∶1∶1∶5.5(质量比)。所制备的纳米乳澄清透明,透射电子显微镜下呈球形,平均粒径为20.4 nm;经高速离心,置于4℃、室温和60℃条件下考察10天,均未见明显变化。结论该制备工艺简单,所制纳米乳稳定性良好。 Objective To prepare the sesame oil nanoemulsion and evaluate its quality. Methods Tween80, Cremophor EL, poloxamer 188 as emulsifier, ethanol, 1,2-propanediol, PEG400 as emulsifier, and Euphorbia oleifera oil as the oil phase, Good prescription, and examine its morphological characteristics and stability. The results of the best prescription: Tween80: absolute ethanol: Euphorbia oil: water = 3: 1: 1: 5.5 (mass ratio). The prepared nanoemulsion was clear and transparent and spherical under a transmission electron microscope with an average particle diameter of 20.4 nm. No significant changes were observed after high-speed centrifugation at 4 ° C, room temperature and 60 ° C for 10 days. Conclusion The preparation process is simple, the stability of the nanoemulsion made good.