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目的探讨人乳头瘤病毒感染及其基因型别与宫颈病变的关系。方法对186例宫颈液基细胞学检查异常患者行HPV-DNA检测和阴道镜下多点活检及组织病理学检查,并分析HPV感染率及其主要基因型别与宫颈病变的关系。结果 186例中HPV-DNA阳性率22.0%(41/186),正常或宫颈炎组为3.8%(5/130)、CIN1组为40.0%(10/25)、CIN2-3组为80.0%(20/25)、宫颈癌组为100%(6/6)。HPV的型别分布以HPV16/58/18最常见,所检出的型别以HPV16检出率最高。结论①HPV感染与宫颈病变的严重程度有关;②高级别宫颈癌前病变与宫颈癌均伴有高危型HPV感染,HPV16最常见。
Objective To investigate the relationship between human papillomavirus (HPV) infection and genotypes and cervical lesions. Methods 186 cases of cervical cytology-based cytology abnormalities were detected by HPV-DNA and colposcopy biopsy and histopathological examination, and analysis of HPV infection rate and its main genotypes and cervical lesions. Results The positive rate of HPV-DNA was 22.0% (41/186) in 186 cases, 3.8% (5/130) in normal or cervicitis group, 40.0% (10/25) in CIN1 group and 80.0% in CIN2-3 group 20/25), cervical cancer group was 100% (6/6). The distribution of HPV type HPV16 / 58/18 most common, the type detected by HPV16 highest detection rate. Conclusions ①PV infection is related to the severity of cervical lesions. ②High-grade cervical precancerous lesions and cervical cancer are associated with high-risk HPV infection, HPV16 is the most common.