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目的观察乳酸氟罗沙星(FLSα)对肺结核的临床疗效。方法初治者给FLSα0.2g,每天2次口服,连用2个月,同时给母牛分枝杆菌菌苗(Vaccae,简称微卡)22.5μg,以注射用水溶解成1ml,深部肌注,10d1次,连用3个月,同时给2HRZ/7HR抗结核药物。复治者给FLSα和微卡剂量方法同上,并给9个月的力克肺疾0.5g,每天3次,利福喷丁0.6g,每周2次,早晨空腹服用。结果41例肺结核,菌阳26例阴转24例,阴转率92.3%;病灶显效37例,显效率90.2%,好转2例,无效2例,总有效率95.1%;空洞11例,闭合10例,闭合率90.9%。副反应1例,出现严重失眠而停药不作统计。结论强化期使用FLSα,对初复治肺结核病例,不论对痰菌阴转、病灶吸收、空洞闭合均有显著效果,且副反应少,值得推广。
Objective To observe the clinical effect of fleroxacin lactate (FLSα) on pulmonary tuberculosis. Methods The naive patients were given FLSα0.2g orally twice daily for 2 months, while giving Vaccine (Vaccae) 22.5μg to 1ml water for injection, deep intramuscular injection, 10d1 Times, once every 3 months, at the same time to 2HRZ / 7HR anti-TB drugs. Treatment of patients with FLSα and micro-card dose method Ibid, and to 9 months of Lectra lung disease 0.5g, 3 times a day, rifapentine 0.6g, 2 times a week, taking an empty stomach in the morning. Results Among the 41 cases of pulmonary tuberculosis, 26 cases were negative for 24 cases, the negative conversion rate was 92.3%, 37 cases were markedly effective, effective rate was 90.2%, 2 cases were improved, 2 cases were ineffective, total effective rate was 95.1%, 11 cases were empty, 10 closed For example, the closure rate of 90.9%. 1 case of side effects, severe insomnia and withdrawal without statistics. Conclusions The use of FLSα in intensive phase has a significant effect on initial treatment of pulmonary tuberculosis, which has significant effects on sputum negative conversion, lesion absorption and cavity closure with less side effects and is worthy of promotion.