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虽然目前已有各种广谱抗生素可供应用,但中性白细胞减少症病人并发革兰氏阴性菌败血症的死亡率仍然很高。作者用SPF雌性SD大鼠以环磷酰胺诱发中性白细胞减少症并进行绿脓杆菌致死性感染试验建立了一个类似于临床抗肿瘤化疗病人细菌感染的动物模型,用以研究单独使用抗-TNF单克隆抗体(McAb)或与抗生素(ciprofloxacin)合用治疗绿脓杆菌致死性感染动物的效果。按步骤制备动物模型,在0和120小时给
Although various broad-spectrum antibiotics are currently available, the mortality of patients with neutropenia who have Gram-negative sepsis is still high. The authors used SPF female SD rats to cyclophosphamide-induced neutropenia and Pseudomonas aeruginosa lethal infection test to establish a similar animal model of clinical anti-tumor chemotherapy in patients with bacterial infection to study the use of anti-TNF Monoclonal antibody (McAb) or in combination with antibiotics (ciprofloxacin) in the treatment of lethal infections caused by Pseudomonas aeruginosa effect. Animal models were prepared by steps, given at 0 and 120 hours