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用单克隆抗体治疗癌症的尝试已经因与正常组织的高交叉反应性和肿瘤抗原的异质性而受阻。现在,国家癌症研究所(马里兰州贝塞斯达)的研究人员已经鉴定了一种单克隆抗体,当它与一个细菌毒素连接的时候,显示出很强的抗卵巢肿瘤细胞的作用,但是与正常组织仅有很有限的反应,研究者们筛选了由卵巢瘤细胞株 OVCAR-3免疫的小鼠获得的杂交瘤,然后将它们的脾淋巴细胞与 NS-1 细胞融合,发现了一株能与所有的卵巢肿瘤组织样品和细胞株反应的杂交瘤,这一杂交瘤还能与几种其它的肿瘤细胞类型反应。这种单克隆抗体还与试验的22
Attempts to treat cancer with monoclonal antibodies have been impeded by the high cross-reactivity with normal tissues and the heterogeneity of tumor antigens. Now, researchers at the National Cancer Institute in Bethesda, Maryland, have identified a monoclonal antibody that shows a strong anti-ovarian tumor cell effect when it is linked to a bacterial toxin, In normal tissue with only a limited response, the researchers screened hybridomas from mice immunized with ovarian tumor cell line OVCAR-3 and then fused their splenic lymphocytes to NS-1 cells and found a The hybridoma that responds to all ovarian tumor tissue samples and cell lines is also capable of reacting with several other tumor cell types. This monoclonal antibody was also tested with 22