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新型血管紧张素转化酶和中性肽链内切酶的双重抑制剂 ,在作用机制上较单纯ACE抑制剂有一定的优越性。它们通过抑制ACE和NEP的活性而发挥降低血压 ,增加体内ANP水平 ,促进尿钠排泄的作用。同时还具有抑制心肌肥厚 ,改善心、肾功能等作用。因此ACE和NEP双重抑制剂为高血压和心衰的治疗开辟了一条新途径。本文简要综述其药理作用机制、构效关系和研究开发现状
Novel angiotensin-converting enzyme and neutral endopeptidase dual inhibitor, in the mechanism of action than ACE inhibitors alone has some advantages. They exert the effects of lowering blood pressure, increasing the level of ANP in vivo and promoting urinary sodium excretion by inhibiting the activity of ACE and NEP. At the same time also has inhibition of cardiac hypertrophy, improve heart, kidney function and so on. Therefore, dual inhibitors of ACE and NEP have opened up a new avenue for the treatment of hypertension and heart failure. This article briefly reviews its pharmacological mechanism, structure-activity relationship and research and development status quo