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目的探讨肿瘤相关性骨软化症(TIO)并进行相关文献复习。方法选取2015年6月至2016年2月收治的3例TIO患者临床资料,随访至2016年10月,并行相关文献复习。结果 3例均表现为进行性加重骨痛、肌痛。3例均显示低血磷、高尿磷以及碱性磷酸酶升高,影像学检查示骨软化。2例查见体表肿物,1例查见牙龈肿物,3例均行诊断性治疗手术切除肿物,病理为磷酸盐尿性间叶肿瘤(PMT),诊断为TIO。术后随访生化指标及临床症状均明显改善。结论 TIO是一种罕见的副肿瘤综合征,一般生长缓慢且位置隐匿,临床易误诊或漏诊,但手术切除肿瘤后,患者预后良好。由此可见,临床及时发现肿瘤非常重要。
Objective To investigate tumor related osteomalacia (TIO) and review related literatures. Methods The clinical data of 3 patients with TIO admitted from June 2015 to February 2016 were selected and followed up until October 2016. The related literature was reviewed. Results 3 cases showed progressive increase of bone pain, myalgia. 3 cases showed hypophosphatemia, high urinary phosphate and alkaline phosphatase increased imaging showed bone osteomalacia. 2 cases of body surface tumor, 1 case of gingival mass, 3 cases underwent surgical resection of the tumor, the pathology of phosphate-based urothelial cell tumor (PMT), the diagnosis of TIO. Follow-up biochemical indicators and clinical symptoms were significantly improved. Conclusion TIO is a rare paraneoplastic syndrome. It usually grows slowly and has a hidden position. It is easy to be misdiagnosed or misdiagnosed, but the prognosis is good after tumor removal. Thus, clinical timely detection of tumors is very important.