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杀虫草(SCD)是沙蚕毒(NTX)系新杀虫剂,国内已广泛应用,临床中毒病例也屡有报道。对麻醉家兔腓总神经胫骨前肌,iv SCD7.5 mg/kg可完全抑制自主呼吸和诱发肌肉收缩。iv二巯基丙磺酸钠(DMPS)7和10mg/kg,可使自主呼吸及肌肉收缩完全恢复。解救兔SCD急性中毒实验中,iv DMPS 62.5mg/kg治疗SCD 15.5 mg/kg中毒,在拮抗肌松及呼吸后,出现震颤、惊厥和EEG发作性异常放电波。增加剂量不能拮抗中枢性作用。DMPS合用iv 5 mg/kg安定能迅速而完
Cordyceps Sinensis (SCD) is a neotocericidal agent (NTX) of new insecticides, has been widely used in China, clinical poisoning cases have also been reported. On anesthetized rabbit common peroneal nerve tibialis anterior muscle, iv SCD7.5 mg / kg can completely inhibit spontaneous breathing and induce muscle contraction. iv Sodium dimercaptopropanesulfonate (DMPS) 7 and 10 mg / kg, can be fully resumed spontaneous breathing and muscle contraction. Rescue rabbit SCD acute poisoning experiment, iv DMPS 62.5mg / kg treatment of SCD 15.5 mg / kg poisoning, in antagonizing muscle relaxation and breathing, there tremor, convulsions and EEG episodes abnormal discharge wave. Increasing the dose can not antagonize the central role. DMPS combined iv 5 mg / kg stability can be quickly finished