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目的 研究在碘缺乏和碘过多的情况下 ,大鼠体内红细胞免疫功能与 SOD活性变化。方法 实验利用低碘饲料和碘化钾去离子水复制了不同碘营养状态的大鼠 ,采用 C3b致敏和未致敏的酵母菌及黄嘌呤氧化酶法分别检测红细胞膜上的 C3b受体、免疫复合物及红细胞内 SOD的活性。结果 碘过多时 ,大鼠红细胞 C3b受体花环率、红细胞免疫复合物花环率及红细胞内 SOD活性均较对照组明显增高 ,碘缺乏时与对照组比较差异无显著意义。结论 碘过多时会引起机体红细胞免疫功能的亢进 ,这可能也是构成高碘引起甲状腺肿自身免疫反应发病机制的因素之一。
Objective To study the changes of erythrocyte immune function and SOD activity in rats with iodine deficiency and iodine excess. Methods Experiments using low-iodine feed and potassium iodide deionized water replication of different iodine nutritional status of rats, C3b sensitized and non-sensitized yeast and xanthine oxidase method were detected on the erythrocyte membrane C3b receptors, immune complexes And erythrocyte SOD activity. Results When the iodine was too much, the rosette of C3b receptor, the rosette of erythrocyte immune complex and the activity of SOD in erythrocytes were significantly higher than those in control group. There was no significant difference between iodine deficiency group and control group. Conclusions Iodine excess can cause the increase of erythrocyte immune function, which may also constitute one of the factors of the pathogenesis of high iodine-induced thyroid autoimmune reaction.