现有的造血理论认为,与髓系一样,淋系来源于淋巴干细胞,但是淋系的发育过程比髓系复杂,已知的淋系肿瘤也更多。WHO 2016分类包括的淋系肿瘤超过50种,B淋巴细胞(下文均简称为B细胞)和T淋巴细胞肿瘤的发病占了90%以上,在分类、临床特征和病理机制上T淋巴细胞肿瘤比B细胞肿瘤复杂,发病率相对较低,本文将重点阐述常见的慢性B淋巴细胞淋巴瘤的来源、基因改变和相关发病机制~([1])。1 B细胞的发育B细胞的发育经历一个从骨髓到外周血和淋巴组织的循 Existing hematopoietic theory that, like the same as the myeloid, lymphatic derived from lymphoid stem cells, but the development of lymphoid lineage complex than the myeloid, lymphoid neoplasms are also known more. WHO classification of the WHO 2016 includes more than 50 types of lymphoid tumors, B lymphocytes (hereinafter referred to as B cells) and T lymphocyte tumors accounted for more than 90% incidence in the classification, clinical features and pathological T lymphocyte tumor ratio B-cell tumors are complex and have a relatively low incidence. This article will focus on the origins, gene alterations and related pathogenesis of common chronic B-cell lymphoma (1). 1 B cell development B cell development goes through a process from bone marrow to peripheral blood and lymphoid tissues