美国旧金山消息:一些研究表明,两种不同药物可有效地促进十二指肠溃疡的愈合。虽然还看不出是否比现用制剂明显优越,但至少有一种药的严重副作用较少。据迈阿密大学内科教授Jeffrey B Raskin报道,在有14个中心参加的双盲研究中,Pirenzepine治疗活动性十二指肠溃疡或幽门溃疡的愈合速度明显比安慰剂快,尤以第四周明显。 Pirenzepine是一种抗毒蕈碱样药物,但与典型的抗毒蕈碱样药物不同,具有选择性抗胆碱作用,抑制胃酸分泌,而无阻断平滑肌或引起心动过速的副作用。该药已由Boehringer Ingelheim在40个国家销售。在多中心的试验中,219例患者分别服用50mg的 SAN FRANCISCO, USA: Some studies show that two different drugs can effectively promote the healing of duodenal ulcers. Although there is no indication of any significant advantage over the active ingredient, at least one has less serious side effects. According to Jeffrey B Raskin, a professor of medicine at the University of Miami, Pirenzepine was significantly faster than placebo in the treatment of active duodenal or pyloric ulcers in a double-blind study of 14 centers, especially in the fourth week. Pirenzepine is an anti-muscarinic-like drug that, unlike typical anti-muscarinic drugs, has a selective anticholinergic effect that inhibits gastric acid secretion without blocking the smooth muscle or causing tachycardia. The drug is marketed in 40 countries by Boehringer Ingelheim. In the multicenter trial, 219 patients took 50 mg each