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目的探讨核黄素转运蛋白(RFT2)在维吾尔族妇女宫颈癌中的表达及临床意义。方法收集维吾尔族妇女宫颈癌患者癌组织标本及癌旁组织的正常宫颈黏膜石蜡包埋组织标本各30例;利用免疫组织化学方法检测宫颈癌组织标本及癌旁组织标本中RFT2表达水平。结果宫颈癌组织中RFT2表达水平为93.3%,其中强阳性、中度阳性、弱阳性、阴性表达率分别为40%、37%、17%、7%,癌旁组织中强阳性、中度阳性、弱阳性、阴性表达率分别为14%、27%、33%、27%。宫颈癌及癌旁组织中RFT2表达差异有统计学意义(P<0.05)。RFT2阳性表达与临床分期、淋巴结转移情况无关(P>0.05)。结论 RFT2高表达可能对维吾尔族妇女宫颈癌发生起促进作用。
Objective To investigate the expression and clinical significance of riboflavin transporter (RFT2) in Uigur women with cervical cancer. Methods The specimens of cervical cancer from 30 Uyghur women and 30 normal cervical mucosa paraffin-embedded tissues of adjacent tissues were collected. The expression of RFT2 in cervical cancer tissues and adjacent tissues was detected by immunohistochemistry. Results The positive expression rate of RFT2 in cervical cancer was 93.3%. The positive rate of RFT2 was 40%, 37%, 17%, 7% in strong positive, moderate positive and weak positive respectively. , Weak positive, negative expression rates were 14%, 27%, 33%, 27%. The expression of RFT2 in cervical cancer and paracancerous tissues had statistical significance (P <0.05). RFT2 positive expression had no correlation with clinical stage and lymph node metastasis (P> 0.05). Conclusion The high expression of RFT2 may promote the occurrence of cervical cancer in Uighur women.