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在以往的文献中,作者发现,对绝经前晚期乳腺癌患者,切除卵巢的临床效果与雌激素受体(ER)水平有关,特别是当ER浓度超过25fmol/mg时,临床治疗效果最好(81.8%)。ER浓度对绝经前晚期乳腺癌患者,选择双侧卵巢切除治疗具有最好的手术评价。当ER浓度较低时(5～10fmol/mg),临床治疗效果则较差(67%～68%)。在本文研究中,作者根据肿瘤组织中不同的ER水平估计存活情况,以期明确治疗效果和存活时间延长是否与高ER水平
In previous literature, the authors found that the clinical effect of ovariectomy on postmenopausal women with advanced breast cancer is related to the level of estrogen receptor (ER), especially when the ER concentration exceeds 25 fmol/mg, the clinical treatment effect is best ( 81.8%). ER concentration has the best surgical evaluation for patients with premenopausal advanced breast cancer who opt for bilateral ovariectomy. When the ER concentration is low (5 to 10 fmol/mg), the clinical treatment effect is poor (67% to 68%). In this study, the authors estimated survival based on different ER levels in the tumor tissue to determine whether the treatment effect and prolonged survival were associated with high ER levels.