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目的观察更昔洛韦联合小剂量丙种球蛋白(IVIG)治疗巨细胞病毒感染的疗效。方法将2009年1月至2012年12月在我院住院的巨细胞病毒感染36例婴儿随机分成两组,每组18例。治疗组在常规治疗基础上加用更昔洛韦5mg/kg,静滴,每12小时1次,连用14天,维持量5mg/kg,每天1次,连用14天,同时给予小剂量丙种球蛋白,每周1次,每次2.5g。对照组予常规保肝抗感染治疗(分组征得家属的知情并签署临床知情同意书)。结果治疗组和对照组在疗程结束后,在临床表现、实验室检查及病毒学结果转归方面进行比较,差异有显著性(P<0.05)。结论更昔洛韦联合小剂量IVIG治疗巨细胞病毒感染疗效好,不良反应少。
Objective To observe the curative effect of ganciclovir combined with low dose gamma globulin (IVIG) on cytomegalovirus infection. Methods Thirty-six infants with cytomegalovirus infection hospitalized in our hospital from January 2009 to December 2012 were randomly divided into two groups, 18 cases in each group. The treatment group was treated with ganciclovir 5mg / kg on the basis of routine treatment, intravenous drip once every 12 hours, once daily for 14 days, maintenance dose 5mg / kg once daily for 14 days, Protein, once a week, each 2.5g. The control group was given conventional liver protection and anti-infection treatment (sub-group informed of family members and signed clinical informed consent). Results After treatment, the treatment group and the control group had significant differences (P <0.05) in clinical manifestations, laboratory tests and virological outcomes. Conclusion Ganciclovir combined with low dose IVIG treatment of cytomegalovirus infection with good efficacy, fewer adverse reactions.