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硼氢化钠是一种温和的选择性还原剂,在一般条件下只能还原醛、酮和酰卤,对其它化合物,如亚砜、腈等则不起作用,因而限制了其应用范围。据文献据道,某些金属盐能有效地提高硼氢化钠的还原能力,最近我们报道了硼氢化钠和六水合三氯化铁在还原亚砜为硫醚的反应中,此复合还原剂比其它试剂具有明显的优点,本工作继续研究了硼氢化钠/铁盐还原腈类化合物为相应的伯胺的反应。
Sodium borohydride is a mild and selective reductant that can only reduce aldehydes, ketones and acyl halides under normal conditions and does not work for other compounds such as sulfoxides and nitriles, thus limiting its range of applications. According to the literature, it is reported that some metal salts can effectively improve the reduction ability of sodium borohydride. Recently, we reported that sodium borohydride and ferric chloride hexahydrate in the reaction of reducing sulfoxide as thioether, the composite reducing agent ratio Other reagents have obvious advantages. This work continues to study the reaction of sodium borohydride / iron salt reducing nitrile compounds with the corresponding primary amines.