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目的:观察中西医结合治疗急性重症胰腺炎患者的效果。方法:将102例急性重症胰腺炎患者随机分为2组,对照组50例采用常规治疗,观察组52例以常规疗法联合中药通腑清胰方治疗,5天为1疗程,治疗2疗程。比较2组患者的肛门排气时间、排便时间、肠鸣音恢复时间、腹痛腹胀缓解时间,治疗前后检测血淀粉酶(AMY)、血肌酐(SCr)、尿素氮(BUN)等生化指标和肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、超敏C-反应蛋白(hs-CRP)等炎症指标的水平。结果:治疗后,观察组肛门排气时间、排便时间、肠鸣音恢复时间、腹痛腹胀缓解时间均较对照组缩短,差异均有统计学意义(P<0.05)。2组AMY、BUN、SCr和TNF-α、hs-CRP、IL-6水平均较治疗前降低,差异均有统计学意义(P<0.05);观察组各指标水平均低于对照组,差异均有统计学意义(P<0.05)。结论:采用常规疗法联合通腑清胰方治疗急性重症胰腺炎效果显著,可有效抑制炎症反应,并促进胃肠功能的恢复。
Objective: To observe the effect of integrated traditional Chinese and western medicine in the treatment of acute severe pancreatitis. Methods: A total of 102 patients with severe acute pancreatitis were randomly divided into two groups. The control group (50 cases) was treated by conventional therapy. The observation group (52 cases) was treated by conventional therapy combined with traditional Chinese medicine Tongfu Qingyao decoction for 5 days for 1 course of treatment for 2 courses. Anal exhaust time, defecation time, bowel sounds recovery time, abdominal pain and abdominal distension time were compared between the two groups before and after treatment, biochemical indicators such as serum amylase (AMY), serum creatinine (SCr), blood urea nitrogen (BUN) The levels of TNF-α, IL-6 and hs-CRP were measured. Results: After treatment, the anal exhaust time, defecation time, bowel sounds recovery time, abdominal pain and abdominal distension time in the observation group were shorter than those in the control group (P <0.05). The levels of AMY, BUN, SCr and TNF-α, hs-CRP and IL-6 in the two groups were significantly lower than those before treatment, with statistical significance (P <0.05) All were statistically significant (P <0.05). Conclusion: The treatment of acute severe acute pancreatitis by conventional therapy combined with Tongfu Qingyao decoction has remarkable effect, which can effectively inhibit the inflammatory reaction and promote the recovery of gastrointestinal function.