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目的探讨孟鲁司特联合布地奈德治疗老年支气管哮喘的临床疗效。方法选取峨边彝族自治县中医医院2015年8月—2016年8月收治的老年支气管哮喘患者80例。根据治疗方案不同分成对照组与观察组,各40例。对照组予以常规治疗,观察组患者在对照组基础上加入孟鲁司特与布地奈德治疗,两组患者均治疗8周。比较两组患者临床疗效、症状缓解时间、肺功能指标〔用力肺活量(FVC)、第1秒用力呼气容积(FEV_1)、呼气峰流速(PEFR)〕及不良反应发生情况,随访6个月,观察两组患者复发情况。结果治疗后观察组总有效率高于对照组,喘息、胸闷、咳嗽缓解时间短于对照组,FVC、FEV_1、PEFR高于对照组(P<0.05)。两组患者治疗期间均未发生严重不良反应。两组患者复发率比较,差异无统计学意义(P>0.05)。结论孟鲁司特联合布地奈德治疗老年支气管哮喘的临床疗效确切,可有效改善患者肺功能,缩短症状缓解时间,降低复发率。
Objective To investigate the clinical efficacy of montelukast combined with budesonide in the treatment of elderly bronchial asthma. Methods Eighty elderly patients with bronchial asthma admitted from August 2015 to August 2016 in Ebian Yi Autonomous County Chinese Medicine Hospital were enrolled. According to different treatment programs were divided into control group and observation group, 40 cases each. Patients in the observation group were treated with montelukast and budesonide on the basis of the control group, and both groups were treated for 8 weeks. The clinical efficacy, symptom relief time, pulmonary function indexes (FVC, FEV_1, PEFR) and incidence of adverse reactions were compared between the two groups. The patients were followed up for 6 months , Observed the recurrence of two groups of patients. Results After treatment, the total effective rate in observation group was higher than that in control group. The wheezing, chest tightness and cough relief time were shorter than those in control group. The FVC, FEV 1 and PEFR were higher in the observation group than in the control group (P <0.05). Two groups of patients during the treatment did not occur serious adverse reactions. There was no significant difference in recurrence rate between the two groups (P> 0.05). Conclusion Montelukast combined with budesonide in elderly patients with bronchial asthma clinical curative effect is exact, can effectively improve lung function, shorten the time to relieve symptoms and reduce the recurrence rate.