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胃癌最常见的术后复发是腹膜复发,但用抗癌药的水溶液经腹膜给药,预防效果不理想。常用抗癌药的小水溶性分子通过毛细血管壁被迅速吸入到下腹膜内。所以,在腹膜腔中抗癌药的有效浓度不能持久保持。作者研究了应用缓释抗癌制剂,吸附于活性炭上的丝裂霉素(M-CH)预防胃癌术后腹腔种植转移,取得良好效果。
The most common postoperative recurrence of gastric cancer is peritoneal recurrence, but the use of anticancer drugs in aqueous solution via the peritoneal administration, the preventive effect is not ideal. The small water-soluble molecules of commonly used anticancer drugs are rapidly inhaled into the lower peritoneum through the capillary wall. Therefore, the effective concentration of anticancer drugs in the peritoneal cavity cannot be maintained for a long time. The authors studied the use of sustained-release anti-cancer preparations and mitomycin C (M-CH) adsorbed on activated charcoal to prevent post-surgical gastric cancer from transplanting in the abdominal cavity and achieved good results.