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目的:研究丙戊酸钠对血浆纤维蛋白原的影响。方法:采用回顾性调查的方法,对符合入选标准的使用丙戊酸钠出现血浆纤维蛋白原降低的15位住院患者的一般情况、丙戊酸钠的用药情况、停药前后纤维蛋白原含量进行调查和分析。结果:患者平均用药时间(18.64±15.46)个月,平均用药剂量(15.49±7.12) mg·kg~(-1)·d~(-1),平均纤维蛋白原含量(1.51±0.19)g·L~(-1),平均停药时间(7.73±3.76)d后,纤维蛋白原量为(3.52±1.61)g·L~(-1)。结论:丙戊酸钠可致血浆纤维蛋白原降低。
Objective: To study the effect of sodium valproate on plasma fibrinogen. Methods: A retrospective survey was conducted to evaluate the general condition of 15 inpatients who had reduced plasma fibrinogen using sodium valproate in compliance with the inclusion criteria, the drug use of sodium valproate, and the fibrinogen content before and after discontinuation Investigate and analyze. Results: The average duration of medication was (18.64 ± 15.46) months, the average dosage was 15.49 ± 7.12 mg · kg -1 · d -1 and the average fibrinogen was 1.51 ± 0.19 g · The average amount of fibrinogen was (3.52 ± 1.61) g · L ~ (-1) after treatment with L ~ (-1) and the average withdrawal time (7.73 ± 3.76) days. Conclusion: Sodium valproate can reduce plasma fibrinogen.