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微小RNA(miRNA)是由长为18～25个核苷酸组成的内源性非编码单链小RNA,通过与特定的靶mRNA结合来抑制mRNA翻译过程而调节基因的表达,与恶性肿瘤的发生、发展、侵袭、转移密切相关。miR-203是一类来源于上皮基底细胞且特异性高表达于上皮细胞的非编码小RNA,由于其与恶性肿瘤的高度相关性及表达矛盾性,近年来已经成为miRNA领域的研究热点。现就miRNA-203在不同恶性肿瘤中表达及其甲基化、靶基因等热点研究进展予以综述。
MicroRNAs (miRNAs) are small, endogenous non-coding single-stranded RNAs consisting of 18 to 25 nucleotides in length that regulate gene expression by inhibiting mRNA translation by binding to specific target mRNAs, Occurrence, development, invasion, transfer are closely related. miR-203 is a type of small non-coding RNA derived from epithelial basal cells and highly expressed in epithelial cells. Because of its high correlation with malignant tumors and its contradictory expression, miR-203 has become a hot spot in the field of miRNA. Now miRNA-203 expression in different malignancies and methylation, target genes and other hot research progress are reviewed.