论文部分内容阅读
目的:探讨葛根芩连五炭汤内外合治活动期溃疡性结肠炎的临床效果。方法:按照入院顺序随机将92例活动期溃疡性结肠炎患者分为实验组46例和对照组46例,分别给予葛根芩连五炭汤内外合联合柳氮磺吡啶治疗和单纯柳氮磺吡啶治疗,比较两组治疗效果。结果:实验组患者治疗总有效率和中医证候总有效率均明显高于对照组;实验组患者治疗后主症积分和总积分均明显低于对照组;实验组患者治疗后肠黏膜病变活动指数明显低于对照组;实验组患者治疗后血清TNF-α、IL-6、IL-8水平均明显低于对照组。结论:葛根芩连五炭汤内外合治活动期溃疡性结肠炎,在改善临床症状、肠黏膜病变以及相关细胞因子方面效果显著。
Objective: To investigate the clinical effect of Gegen Qinlian Peujian Decoction on active ulcerative colitis in both internal and external medicine. Methods: 92 patients with active ulcerative colitis were randomly divided into experimental group (n = 46) and control group (n = 46) according to the order of admission. The rats were treated with Gegen Qinlian Decoction combined with sulfasalazine and sulfasalazine alone Treatment, the treatment effect of two groups were compared. Results: The total effective rate of treatment and the total effective rate of TCM syndrome in experimental group were significantly higher than those in control group. The scores of main symptom and total score in experimental group were significantly lower than those in control group. The intestinal mucosal lesions in experimental group The indexes in the experimental group were significantly lower than those in the control group. The levels of TNF-α, IL-6 and IL-8 in the experimental group were significantly lower than those in the control group after treatment. Conclusion: The effect of Gegen Qinlian Wuzhu Tang combined with active and active ulcerative colitis is significant in improving clinical symptoms, intestinal mucosal lesions and related cytokines.