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本文综合报道了615系小鼠乳腺癌自发瘤Ca841、Ca842和乳腺瘤株Ca759、Ca761、Ca763移植瘤的透射电镜观察。Ca841、Ca842、Ca761、Ca763的原代瘤光镜诊断符合Duun氏小鼠乳腺癌分类的A型,而Ca759则为B型。在超微结构方面,它们之间相似之处主要表现在瘤细胞均呈现不同程度的多形性,核质此高,核仁明显,可见核分裂相,表面有微绒毛,细胞间有细胞连接,胞质中均可见A型病毒样颗粒,核糖体特别丰富而其它细胞器较少。综上符合一般癌细胞的特征。它们之间不同之处,在Ca841、Ca842,其瘤细胞与肌上皮样细胞形成腺泡样结构,含有A型和B型两种病毒样颗粒,瘤细胞可分明、暗二型;Ca759瘤细胞多紧排列成癌巢,也有明、暗二型瘤细胞;Ca761、Ca763瘤细胞排列较分散,不能区分明、暗细胞,其细胞器较丰富除含大量多聚核蛋白体外,尚可见高尔基复合体和微丝。除Ca761外,均可见基膜。在Ca761有时可见从中心粒直接发出伸向细胞表面的纤毛。就我们所见,进行了讨论。其中特别值得提出的是:原代A型乳腺癌在移植过程中有的可转变成B型;存在于原代癌中的A型及B型病毒颗粒在移植中B型颗粒多丧失而A型颗粒可持续存在;明细胞与暗细胞似乎是处于不同功能状态的同一细胞,暗细胞可能处于功能活跃状态;某些瘤细胞中所见的微纤维与瘤细胞的活动与侵袭可能存在一定关系。另外,令人感兴趣的是Ca763的某些瘤细胞中,可见有从中心粒发出的纤毛,这点在其它文献中尚未见报道。
This article comprehensively reported the transmission electron microscopic observation of the 615-line mouse breast cancer spontaneous tumor Ca841, Ca842 and breast cancer Ca759, Ca761, Ca763 transplanted tumor. The primary neoplasm diagnosis of Ca841, Ca842, Ca761, Ca763 conformed to type A of Duun’s breast cancer classification, whereas Ca759 was type B. In the ultrastructure, the similarities between them are mainly manifested in the tumor cells showed varying degrees of polymorphism, the high quality of nuclei, nucleoli were obvious, visible mitotic phase, surface microvilli, cell connections between cells, Type A virus-like particles are visible in the cytoplasm, with particularly abundant ribosomes and fewer organelles. In summary, in line with the general characteristics of cancer cells. The difference between them, in Ca841, Ca842, the tumor cells and myoepithelial-like cells to form acinar-like structure, containing type A and type B virus-like particles, tumor cells can be clearly, dark type; Ca759 tumor cells Tightly arranged into cancer nests, but also the bright, dark type 2 tumor cells; Ca761, Ca763 tumor cells arranged more dispersed, can not distinguish between bright and dark cells, the organelles are rich in addition to containing a large number of polyriboin in vitro, the visible Golgi complex And Microfilament. In addition to Ca761, are visible basement membrane. It is sometimes seen at Ca761 that cilia extending directly to the cell surface is emitted directly from the centriole. As we saw it, we discussed it. Which is particularly worth mentioning is: some of the original type A breast cancer in the process of transplanting can be transformed into type B; exist in the primary cancer of the A and B virus particles in the transplanted B-type particles and more loss of type A Particles may persist; so-called cells and dark cells appear to be the same cells in different functional states, dark cells may be in a functional state of activity; some of the fibrils seen in some tumor cells may have some relation to the activity and invasion of tumor cells. In addition, it is interesting to note that some of the tumor cells in Ca763 have centriole-derived cilia, which has not been reported in other literatures.