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目的:探讨周围型肺癌CT征象与血管内皮生长因子、E钙黏附蛋白表达间的关系。方法:本组58例周围型肺癌患者均采用螺旋CT扫描,采用免疫组织化学链菌素生物素蛋白-过氧化酶连接法检测肿瘤组织血管内皮生长因子、E钙黏附蛋白的表达。结果:E钙黏附蛋白异常表达32例,血管内皮生长因子异常表达35例,肺癌E钙黏附蛋白的异常表达与肿瘤的大小、棘突征、胸膜侵犯、淋巴转移明显相关(P<0.05)。肺癌血管内皮生长因子的异常表达与毛刺征、棘突征、血管集束征、空洞征胸膜侵犯、淋巴结转移明显相关(P<0.05)。结论:血管内皮生长因子和E钙黏附蛋白异常表达在肺癌的发生、发展及CT表现中可能起重要作用,检测该基因可作为临床诊断及预后评估的指标。
Objective: To investigate the relationship between CT signs and the expression of vascular endothelial growth factor and E-cadherin in peripheral lung cancer. Methods: 58 cases of peripheral lung cancer patients were used spiral CT scan, the use of immunohistochemical streptavidin - peroxidase connection assay of tumor tissue vascular endothelial growth factor, E cadherin expression. Results: E - cadherin expression was abnormal in 32 cases and vascular endothelial growth factor was abnormally expressed in 35 cases. The abnormal expression of E - cadherin in lung cancer was significantly associated with tumor size, spinous process, pleural invasion and lymphatic metastasis (P <0.05). Abnormal expression of vascular endothelial growth factor in lung cancer was significantly associated with spiculation, spina bifida, vascularization, empty pleural invasion and lymph node metastasis (P <0.05). Conclusion: The abnormal expression of vascular endothelial growth factor and E-cadherin may play an important role in the occurrence, development and CT appearance of lung cancer. Detecting this gene may serve as an index for clinical diagnosis and prognosis evaluation.