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目的 :观察更昔洛韦治疗小儿巨细胞病毒 (CMV)肝炎的疗效。方法 :36例CMV肝炎患者分为更昔洛韦治疗组 2 0例及利巴韦林对照组 16例进行比较。结果 :治疗组总有效率为 85 .0 0 % ,明显高于对照组 4 3.75 % (P <0 .0 1)。治疗组和对照组血CMV IgM转阴率分别为 90 .0 0 %和 5 0 .0 0 % ;尿CMV DNA转阴率分别为 80 .0 0 % ,2 5 .0 0 %。结论 :更昔洛韦是治疗小儿CMV肝炎的有效药物
Objective: To observe the curative effect of ganciclovir on children with cytomegalovirus (CMV) hepatitis. Methods: Thirty-six patients with CMV hepatitis were divided into ganciclovir-treated group and control group, ribavirin control group. Results: The total effective rate was 85.0% in the treatment group, which was significantly higher than that in the control group (4.75%, P <0.01). The negative rates of CMV IgM in the treatment group and the control group were 90.0% and 50.0%, respectively. The negative rates of urine CMV DNA were 80.0% and 25.0% respectively. Conclusion: Ganciclovir is an effective drug for treating CMV hepatitis in children