肝纤维化(liver fibrosis)是肝脏内细胞外基质(extracelluarmatrix,ECM)过度沉积性疾病,是各种慢性肝病共有的病理改变,是进一步向肝硬化发展的主要环节。许多因素如慢性肝炎、脂肪肝(酒精性或非酒精性)、血吸虫病、药物性肝病都可造成慢性肝损害,又都可导致肝纤维化。在各种致 Liver fibrosis is an excess deposition disease of the extracellular matrix (ECM) in the liver. It is a common pathological change of various chronic liver diseases and is a major part of the development of liver cirrhosis. Many factors, such as chronic hepatitis, fatty liver (alcoholic or non-alcoholic), schistosomiasis and drug-induced liver disease, can cause chronic liver damage and lead to liver fibrosis. In various sorts