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目的：分析复方泛影葡胺与碘海醇在静脉肾盂造影中的不良反应，为临床选用造影剂提供参考。方法分析我院2010年1月～2013年12月静脉肾盂造影患者的资料，根据其使用的对比剂不同分为复方泛影葡胺组与碘海醇组，对比其在造影过程中出现的不良反应。结果碘海醇在静脉肾盂造影中的不良反应明显低于复方泛影葡胺，两组比较差异有统计学意义。结论在静脉肾盂造影检查中，碘海醇更适合广泛使用，且安全性更高。“,”Objective By analysis of the adverse reactions of compound meglumine diatrizoate and iohexol in intravenous pyelography, which provide a reference for the clinical use of contrast agent. Methods We divided intravenous pyelography patients in our hospital into two groups: compound meglumine diatrizoate group and iohexol group by difference contrast agents during 2010.01 to 2013 .12 and we compared the dates of adverse reactions of two groups. Results There was significant difference between two groups, the adverse reactions of iohexol was significantly lower than that of compound meglumine diatrizoate in intravenous pyelography . Conclusion In intravenous pyelography, iohexol is more suitable a be widely used and higher safety.