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目的研究普通人群血清尿酸(SUA)水平与非酒精性脂肪性肝病(NAFLD)的关系。方法收集27615名体检者的临床和生化资料,并通过腹部B超诊断NAFLD。将研究对象分为非NAFLD(Non-NAFLD)组和NAFLD组,再根据不同性别的SUA四分位数将研究对象分为4组(Q1~Q4),比较各组临床和生化特征。结果本研究中,NAFLD及高尿酸血症(HUA)的患病率分别为27.1%和19.6%。随SUA水平的升高,BMI、SBP、DBP、TG、TC、LDL-C、Scr、ALT和AST均升高,HDL-C降低(趋势P<0.001);从Q1组至Q4组,NAFLD的患病率逐渐递增(13.5%vs 19.9%vs29.3%vs 46.2%,趋势P<0.001);多元Logistic回归分析发现,校正性别、年龄、BMI、BP、血脂等因素后,Q2~Q4组的NAFLD患病风险较Q1组分别增加24%、62%和137%(P<0.001)。结论在普通人群中,SUA与NAFLD密切相关,可能是NAFLD发生的独立危险因素。
Objective To investigate the relationship between serum uric acid (SUA) and non-alcoholic fatty liver disease (NAFLD) in the general population. Methods The clinical and biochemical data of 27,615 subjects were collected and NAFLD was diagnosed by abdominal ultrasonography. The subjects were divided into non-NAFLD group and NAFLD group. According to SUA quartiles of different genders, the subjects were divided into four groups (Q1-Q4), and the clinical and biochemical characteristics of each group were compared. Results The prevalence of NAFLD and hyperuricemia (HUA) in this study was 27.1% and 19.6%, respectively. The levels of BMI, SBP, DBP, TG, TC, LDL-C, Scr, ALT and AST increased and the HDL-C decreased with the increasing of SUA level (trend P <0.001). From Q1 group to Q4 group, The prevalence was gradually increased (13.5% vs 19.9% vs29.3% vs. 46.2%, trend was P <0.001). After multivariate Logistic regression analysis, after adjustment for gender, age, BMI, BP, The risk of NAFLD increased by 24%, 62% and 137%, respectively, compared with Q1 group (P <0.001). Conclusion In the general population, SUA is closely related to NAFLD and may be an independent risk factor for NAFLD.