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目的:探讨DNAJB6蛋白在乳腺癌中的表达及临床意义。方法:采用免疫组织化学的方法检测78例乳腺癌组织DNAJB6蛋白水平的表达,分析其与临床病理特征的关系。结果:DNAJB6蛋白低表达率为62.8%(49/78),DNAJB6蛋白的表达水平与乳腺肿瘤大小、组织学分级负相关(分别为rs=-0.254和rs=-0.293,P<0.05)。结论:DNAJB6蛋白低表达与乳腺癌恶性程度有关。
Objective: To investigate the expression of DNAJB6 protein in breast cancer and its clinical significance. Methods: Immunohistochemistry was used to detect the expression of DNAJB6 protein in 78 cases of breast cancer tissues. The relationship between them and the clinicopathological features was analyzed. Results: The low expression rate of DNAJB6 protein was 62.8% (49/78). The expression of DNAJB6 protein was negatively correlated with the size and histological grade of breast cancer (rs = -0.254 and rs = -0.293, P <0.05, respectively). Conclusion: The low expression of DNAJB6 is associated with the malignant degree of breast cancer.