自1962年美国Sterling-Winthrop研究所Lesher等发现第一个喹诺酮类抗生素萘啶酸以来,许多学者致力于研究开发这类药物,至今已有四代问世。在临床应用广泛,本文就其近年来的研究情况及临床应用作一综述。第一代药物有萘啶酸、西诺沙星、吡哌酸,以萘啶酸为代表;第二代有诺氟沙量 Since the discovery of the first quinolone antibiotic nalidixic acid by Lesher et al. At the Sterling-Winthrop Institute in the United States in 1962, many scholars have devoted themselves to the research and development of such drugs. Four generations have now passed. In a wide range of clinical applications, this article reviews recent research and clinical applications. The first generation of drugs nalidixic acid, cinoxacin, pipemidic acid to nalidixic acid as the representative; the second generation of norfloxacin