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近10年来,新发现16种中药对心活性成分肌缺血再灌注损伤有明确保护作用。这些成分是从23种中草药中分离纯化出来的,多数是具有环状结构的极性分子,具强氧化或强还原性。这16种成分通过调控相关的信号通路,从而发挥清除氧自由基、抑制钙超载及心肌细胞凋亡、干预炎症反应、保护血管内皮功能等作用,从而达到抗心肌缺血再灌注的效果。文章全面概述了这16种成分的分子结构、理化性质、源自何种中草药,以及它们发挥心肌缺血再灌注保护作用的机制,系统总结了10年来中药“补气活血、开胸除痹”的物质基础及作用机制研究进展。
In the past 10 years, 16 kinds of newly discovered traditional Chinese medicines have a clear protective effect on cardiac muscle ischemia-reperfusion injury. These ingredients are isolated from 23 kinds of Chinese herbal medicine purification, most of the polar molecules with a ring structure, with strong oxidation or strong reduction. These 16 kinds of components through the regulation of the relevant signal pathways, thus play a role in scavenging oxygen free radicals, inhibition of calcium overload and cardiomyocyte apoptosis, intervention inflammation, protection of vascular endothelial function, so as to achieve anti-myocardial ischemia-reperfusion effect. The article provides a comprehensive overview of the molecular structure, physicochemical properties, and herbal medicines derived from these 16 components, as well as their mechanisms of exerting the protective effects of myocardial ischemia-reperfusion. "The material basis and mechanism of action research progress.