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目的探讨应用复方甘草酸苷治疗慢性乙型肝炎的临床疗效。方法选取2012年2月至2014年2月在洛阳市第六人民医院收治的120例慢性乙型肝炎患者,随机分为治疗组与对照组,每组60例。对照组应用甘草酸二铵进行治疗,治疗组应用复方甘草酸苷进行治疗,治疗后比较两组患者不良反应及HBV-DNA、HBe Ag转阴等。结果治疗组患者不良反应总发生率(11.66%)明显低于对照组(38.33%),差异有统计学意义(P<0.05);治疗组患者HBV-DNA转阴率(73.30%)明显高于对照组(46.70%),治疗组患者HBe Ag转阴率(38.30%)明显高于对照组(13.30%),差异均有统计学意义(P<0.05)。结论采用复方甘草酸苷治疗慢性乙型肝炎的临床疗效更好,见效更快,能够缓解患者的不良反应,有效抑制病毒再继续复制,在临床上应用更多,更值得推广。
Objective To investigate the clinical efficacy of compound glycyrrhizin in the treatment of chronic hepatitis B. Methods A total of 120 chronic hepatitis B patients admitted to the Sixth People’s Hospital of Luoyang from February 2012 to February 2014 were randomly divided into treatment group and control group, with 60 cases in each group. The control group was treated with diammonium glycyrrhizinate. The treatment group was treated with compound glycyrrhizin. After treatment, adverse reaction and HBV-DNA, HBe Ag negative were compared between the two groups. Results The total incidence of adverse reactions (11.66%) in the treatment group was significantly lower than that in the control group (38.33%), the difference was statistically significant (P <0.05); The HBV-DNA negative rate In the control group (46.70%), the HBeAg negative rate (38.30%) in the treatment group was significantly higher than that in the control group (13.30%), the difference was statistically significant (P <0.05). Conclusion The compound glycyrrhizin in the treatment of chronic hepatitis B has better clinical curative effect, quicker effect, can relieve adverse reactions in patients, and effectively restrain the virus from continuing to be duplicated. It is more widely used in clinic and more worthy of promotion.