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为探究以丹皮酚、马钱苷等指标为主要成分的六味地黄丸溶出度的测定方法,本文以小杯法为主要方法,将200ml脱气人工胃液作为溶出介质,借助高效液相色谱法对六味地黄丸的溶出度进行外标定量,结果发现,丹皮酚、马钱苷分别在4.05-36.26ug/m L和3.03-27.19ug/L范围内呈现出良好的线性关系,实验结果表明,该方法简单可靠且准确性较高,对于六味地黄丸溶出度的测定具有良好的使用和推广价值。
In order to explore the method of determining the dissolution of Liuweidihuangwan pill, which contains paeonol and loganin as the main components, this article takes the small cup method as the main method, and uses 200ml of degassed artificial gastric juice as the dissolution medium and high performance liquid chromatography The results showed that paeonol and loganin showed a good linear relationship in the range of 4.05-36.26 ug / mL and 3.03-27.19 ug / L, respectively. The experimental results showed that , The method is simple and reliable and has high accuracy. It has good use and promotion value for the determination of the dissolution of Liuwei Di Huang Wan.