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氯苯吩嗪多年来用于治疗麻风病,此药也已用于爱滋病患者并发鸟型结核分枝杆菌的复合感染.抗菌活性:氯苯吩嗪迅速与所有分枝杆菌的脱氧核糖核酸(DNA)相结合而干扰其生长.不同的菌种,需要不同的药物浓度才能抑制其生长.此药虽对麻风杆菌有杀菌作用,但很缓慢,要对麻风病人治疗50天以后才能在活组织内找到死亡的麻风杆菌.氯苯吩嗪在试管内还有抗鸟型结核分枝杆菌复合感染的作用,这种鸟型结核分枝杆菌复合感染是爱滋病患者播散感染的常见原因.药物动力学:氯苯吩嗪在胃肠道中吸收缓慢,口服大约有50%最后可到达体循环.此药具有亲脂性,它的结晶蓄积在脂肪组织及网状内皮细胞和巨噬细胞内,并且滞留很长时间.重复口服后,排出半衰期大
Chlorphenazine has been used for many years in the treatment of leprosy and has also been used in the co-infection of AIDS patients with Mycobacterium avicensis Mycobacterium tuberculosis: Antibacterial activity: Clofibrate rapidly associates with all mycobacterial DNA ) To interfere with the growth of their combination of different strains need different concentrations of drugs in order to inhibit its growth Although this drug bactericidal effect on leprosy, but very slowly, to leprosy patients after 50 days of treatment in the living tissue To find the death of leprosy.Miclopidine in the test tube also has the role of anti-avian Mycobacterium tuberculosis complex infection, this bird-type Mycobacterium tuberculosis complex infection is a common cause of AIDS-infected patients disseminated.Pharmacokinetics : Chlorophenazine slowly absorbs slowly in the gastrointestinal tract and approximately 50% of oral administration reaches the systemic circulation Finally, the drug is lipophilic and its crystals accumulate in adipose tissue and in reticuloendothelial cells and macrophages and remain long Time. Repeated oral administration, discharge half-life