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目的探讨肝硬化患者合并感染的危险因素。方法以2004年10月-2008年10月184例肝硬化住院患者为研究对象,采用病例对照的研究方法,回顾性分析感染发生情况和危险因素。结果 64例患者合并细菌感染,感染率34.8%;感染类型主要包括呼吸道感染44例(68.8%),自发性腹膜炎12例(18.8%),标本培养10例阳性结果,革兰染色阴性菌6例,革兰染色阳性菌4例;Logistic多因素分析显示,Child-Pugh分级为C级、年龄>55岁、脾大/脾切除、病毒性肝炎、上消化道出血史是相对独立危险因素,OR值(95%CI)依次为3.341(1.529～7.300)、2.912(1.313～6.460)、2.691(1.164～6.221)、2.651(1.191～5.902)、2.162(1.060～4.410)。结论重视肝硬化患者的病情分级、年龄、病因、并发症,更好地预防控制肝硬化合并感染。
Objective To investigate the risk factors of coinfected cirrhosis patients. Methods A total of 184 inpatients with cirrhosis from October 2004 to October 2008 were enrolled in this study. A case-control study was conducted to analyze the incidence of infection and risk factors. Results Sixty-four patients were infected with bacterial infection, the infection rate was 34.8%. The infection types included respiratory infection in 44 cases (68.8%), spontaneous peritonitis in 12 cases (18.8%), positive specimens in 10 cases, and gram-negative bacteria in 6 cases , Gram-positive bacteria in 4 cases; Logistic multivariate analysis showed that Child-Pugh grading was Grade C, age> 55 years, splenomegaly / splenectomy, viral hepatitis and upper gastrointestinal bleeding were independent risk factors, OR Values (95% CI) were 3.341 (1.529-7.300), 2.912 (1.313-6.460), 2.691 (1.164-6.221), 2.651 (1.191-5.902) and 2.162 (1.060-4.410), respectively. Conclusion The emphasis on patients with cirrhosis grade, age, etiology, complications, and better prevention and control of cirrhosis with infection.