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目的 :探讨喉鳞状细胞癌中人乳头状瘤病毒 (HPV1 6 ,1 8亚型 )感染情况及临床分析。方法 :用免疫组化的方法对 42例喉鳞癌组织中 HPV1 6 ,1 8亚型感染情况进行检测。 结果 :42例喉鳞癌组织中 HPV1 6 ,1 8亚型感染阳性率 6 4.2 9% (2 7/ 42 ) ,但HPV1 6 ,1 8感染与临床分期、癌细胞的分化程度、肿瘤的淋巴结转移和临床分型无关。 结论 :HPV1 6 ,1 8感染可能是人喉癌形成的触发因素 ,它对肿瘤生物学行为的影响似乎不大
Objective: To investigate the infection and clinical analysis of human papillomavirus (HPV1 6, 18 subtype) in laryngeal squamous cell carcinoma. Methods: Immunohistochemistry was used to detect HPV16, 18 subtype infection in 42 cases of laryngeal squamous cell carcinoma. Results: The positive rate of HPV16, 18 subtype infection in 42 cases of laryngeal squamous cell carcinoma was 62.29% (27/42), but the infection and clinical stage of HPV16, 18, the differentiation of cancer cells, the lymph node Metastasis and clinical classification has nothing to do. Conclusion: HPV1 6, 18 infection may be the trigger factor in the formation of human laryngeal carcinoma, and its effect on tumor biological behavior does not appear to be large