论文部分内容阅读
郎格罕细胞(LC)由骨髓CD34~+造血干细胞衍生后便向皮肤迁移,一旦定居在表皮,就呈现出独特的形态和表型特征,反映特异的抗原捕获和处理功能。LC被激活后,体积增大,主要组织相容性(MHC)Ⅱ类分子的表达增高,并移向局部淋巴结,将肽段递呈给原始T细胞(naive T cells)。在体外,这些功能变化伴有特异的免疫表型的改变,而功能和表型的转化似乎主要依赖于粒细胞巨噬细胞集落刺激因子
After being derived from bone marrow CD34 ~ + hematopoietic stem cells, the Langerhans cells (LCs) migrate to the skin and once settled in the epidermis, exhibit unique morphological and phenotypic features that reflect specific antigen capture and processing functions. After LC is activated, the volume increases, and the expression of major histocompatibility (MHC) class II molecules increases and moves to the local lymph nodes, presenting the peptides to naive T cells. In vitro, these changes in function are accompanied by changes in specific immunophenotypes, and the conversion of function and phenotype appears to be largely dependent on granulocyte macrophage colony stimulating factor