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目的观察肝硬化患者口服双歧杆菌四联活菌片后对肠道菌群、血浆内毒素、血氨以及肝功能指标的变化和产生的影响。方法选择7种具有代表性的肠道菌群有针对性进行培养和计数,对照组20例患者给予常规治疗,治疗组22例患者在常规治疗的基础上加服益生菌治疗,疗程为3周。同时观察两组治疗前后血浆内毒素水平、血氨以及肝功能指标变化。结果与肝硬化相比,加服双歧杆菌四联活菌片后消化道症状明显缓解,肠道有益菌增加,血氨下降,肝功能指标好转。结论益生菌可以有效改善肝硬化患者的肠道菌群失调,降低血内毒素和血氨水平,改善肝功能情况。
Objective To observe the effects of oral administration of live Bifidobacterium quadriceps on the changes of intestinal microflora, endotoxin, blood ammonia and liver function in patients with liver cirrhosis. Methods Seven kinds of representative gut microbiota were selected for culture and counting. In the control group, 20 patients were given routine treatment. In the treatment group, 22 patients were treated with probiotics on the basis of routine treatment. The course of treatment was 3 weeks . At the same time, the levels of plasma endotoxin, blood ammonia and liver function were observed before and after treatment. Results Compared with liver cirrhosis, after taking Bifidobacterium quadriceps, the symptom of digestive tract was obviously relieved, the beneficial bacteria in the intestine increased, the blood ammonia decreased, and the liver function improved. Conclusion Probiotics can effectively improve the intestinal flora of patients with liver cirrhosis, reduce blood endotoxin and serum ammonia levels, improve liver function.