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噻唑烷二酮(TZD)包括一系列具有2,4-噻唑烷二酮结构的化合物。它们均具有不同的侧链取代基,因而药理特点各有不同。最近发现一种化合物TZD18,一种兼具有改善胰岛素抵抗和降低甘油三酯、胆固醇作用的PPARα/γ的双重激动剂。本文综述了TZD18在脂质代谢方面的研究进展。
Thiazolidinediones (TZDs) include a series of compounds having a 2,4-thiazolidinedione structure. They all have different side-chain substituents, and thus have different pharmacological properties. Recently, a compound TZD18, a dual agonist with both PPARα / γ with both insulin resistance and triglyceride and cholesterol lowering effects, was found. This article reviews the research progress of TZD18 in lipid metabolism.