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目的:探讨地红霉素对轻中度哮喘儿童支气管高反应性的影响。方法:轻中度哮喘儿童50例,用布地奈德吸入(剂量为轻度哮喘100μg·d~(-1),中度哮喘200μg·d~(-1))4周后,分为A、B两组,进入试验观察。所有病例继续应用糖皮质激素吸入,剂量同前。A组26例,加用地红霉素5mg·kg~(-1),po,每周2次。B组24例,单用布地奈德吸入。试验期为8周。两组在试验开始和结束时均用诱导痰液进行淋巴细胞百分率、嗜酸粒细胞百分率、中性粒细胞百分率检测。结果:A组其诱导痰液的淋巴细胞、中性粒细胞百分率与B组比较,均有统计学差异(P<0.05)。结论:小剂量地红霉素口服8周,并联合吸入糖皮质激素治疗轻、中度哮喘儿童的支气管高反应性明显降低。
Objective: To investigate the effect of D-erythromycin on bronchial hyperreactivity in children with mild to moderate asthma. Methods: 50 children with mild to moderate asthma were treated with budesonide inhalation (100 μg · d -1 for mild asthma and 200 μg · d -1 for moderate asthma), then divided into A, B two groups, enter the experimental observation. All cases continue to use glucocorticoid inhalation, the same dose. A group of 26 cases, plus erythromycin 5mg · kg ~ (-1), po, twice a week. B group 24 cases, single budesonide inhalation. The test period is 8 weeks. Both groups were induced sputum for lymphocyte percentage, eosinophil percentage and neutrophil percentage test at the beginning and end of the experiment. Results: The percentage of lymphocytes and neutrophils induced by sputum in group A was significantly higher than that in group B (P <0.05). CONCLUSION: Bronchial hyperresponsiveness in children with mild or moderate asthma is significantly reduced after oral administration of low dose of erythromycin for 8 weeks and combined inhaled corticosteroids.