患儿女,第3胎,足月顺产,生后3min 自行死亡。羊水过多,约10000ml。否认三代近亲婚配,否认家族畸胎遗传史,其母25岁,既往体健,孕早期曾患“感冒”,无服药史,否认接触放射线及有害物质等。查体:体重2.3kg,身长42cm,头皮、头骨缺损,无大脑,脑实质极少,脑髓暴露,色暗红,有包膜覆盖,双眼突出似蛙眼,双侧唇裂及腭裂,与鼻腔贯通。颈项过短,头部陷于两肩之间。从颈7以下有长7cm、宽3cm Children with children, the third child, full-term spontaneous delivery, 3min after birth to death on their own. Amniotic fluid too much, about 10000ml. Denied the third generation of cousins ​​marriage, deny family genetic history of teratogenicity, the mother 25 years old, past physical health, early pregnancy had “cold”, no medication history, denied exposure to radioactive and harmful substances. Examination: Weight 2.3kg, length 42cm, scalp, skull defect, no brain, brain parenchyma, brain exposed, dark red, covered with a coating, eyes prominent like the frog eye, bilateral cleft lip and cleft palate, and the nasal cavity through . Neck is too short, head caught between the shoulders. From the neck 7 below 7cm long, 3cm wide