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晚期食管癌患者接受单纯放疗后的生存率不高,治疗失败的主要原因是局部未控和远处转移。化疗可起到提高肿瘤局部控制率、预防及治疗肿瘤远处转移的作用,其有效率为35%~55%。放化疗联合应用于食管癌治疗,既能增强肿瘤组织对放疗的敏感性,又能提高化疗药物的治疗效果;二者相互协同,共同阻滞肿瘤进展及转移,最终延长患者的生存时间。因此,在同步放化疗的基础上优化各种化疗方案,成为了近年来局部晚期食管癌研究的热点之一。本文即对不同化疗方案在食管癌临床应用中的放疗增效作用进行综述。
The survival rate of patients with advanced esophageal cancer after radiotherapy alone is not high, the main reason for the failure of treatment is uncontrolled and distant metastasis. Chemotherapy can improve the local control rate of tumor, and prevent and treat the distant metastasis of tumor. The effective rate is 35% -55%. Radiotherapy and chemotherapy combined with esophageal cancer treatment can not only enhance the sensitivity of tumor tissue to radiotherapy, but also improve the therapeutic effect of chemotherapy drugs. The two can work together to block tumor progression and metastasis and eventually prolong the survival time of patients. Therefore, the optimization of various chemotherapeutic regimens on the basis of concurrent chemoradiotherapy has become one of the hot spots in the study of locally advanced esophageal cancer in recent years. This article reviews the different chemotherapy regimens in the clinical application of esophageal cancer radiotherapy and synergies.