论文部分内容阅读
甲状腺在种系发生上是最古老的内分泌腺,也是合成T_4的唯一场所。它还分泌含碘量比T_4少的其它碘化甲腺原氨酸,如3,5,3′-三碘甲腺原氨酸(T_3),3,3′,5′-三碘甲腺原氨酸(简称反T_3或rT_3)及T_2等。虽然,本世纪初即已发现T_4,以后相继又发现了其它几种碘化甲腺原氨酸;但对这些碘化甲腺原氨酸在外周组织的代谢过程一直认识不清,致使对一些生理和病理现象困惑不解。近几十年来,随着研究方法和技术的改进,对碘化甲腺原氨酸的代谢,特别是对它们在外周组织脱碘代谢过程的研究日益深入。
Thyroid gland is the oldest endocrine gland in the phylogeny, but also the only place for the synthesis of T_4. It also secrete other iodated thyronines such as 3,5,3’-triiodothyronine (T_3), 3,3 ’, 5’-triiodothyronine, which have less iodine than T_4 Arginine (referred to as anti-T_3 or rT_3) and T_2 and so on. Although T_4 has been found at the beginning of this century, several other thyroid iodated iodides have subsequently been found; however, the metabolic processes of these iodated thyronines in peripheral tissues have not been well understood, Physiological and pathological phenomena puzzled. In recent decades, with the improvement of research methods and techniques, the research on the metabolism of thyronine iodine iodine, especially its deiodination and metabolism in peripheral tissues, has been deepened.