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目的:研究清胆颗粒制粒工艺。方法:制备清胆颗粒喷雾干燥浸膏粉,采用干压法、流化法、高速搅拌法制备清胆颗粒;以颗粒粒径分布、流动性及成品率为评价指标,优选清胆颗粒制粒工艺。结果:高速搅拌制粒主要为20～30目的颗粒,流化制粒主要为30～60目颗粒,干压制粒粒径分布广、细粒多;流动性顺序为高速搅拌制粒>流化制粒>干压制粒清胆颗粒;成品率顺序为高速搅拌制粒>流化制粒>干压制粒。结论:采用高速搅拌制粒法制备清胆颗粒,效果优于干压法和流化制粒法,工艺可行,可为进一步研究提供理论基础。
Objective: To study the granulation process of Granule. Methods: The preparation of Qinggang granule spray-dried extract powder was prepared by dry-pressure method, fluidization method and high-speed stirring method. Granule size distribution, fluidity and yield were used as evaluation indexes, Process. Results: High speed agitation granulation was mainly composed of 20-30 mesh particles, and fluidized granulation was mainly composed of 30-60 mesh particles. The dry granulation had a wide distribution of particle size and many fine particles. The fluidity order was high speed agitation granulation> fluidization Granulation> Granulation granulation dry granulation particles; the order of yield high-speed mixing granulation> fluidized granulation> dry granulation. Conclusion: The preparation of Qing dang granules by high speed agitation granulation method is better than dry pressing and fluidized granulation. The technology is feasible and can provide theoretical basis for further research.